藥物交互作用
Aprepitant + Lemborexant
嚴重程度: 嚴重
Aprepitant and Lemborexant: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Aprepitant can raise lemborexant exposure through CYP3A4 inhibition. This may cause excess somnolence, next-day impairment and impaired driving ability.
用白話說明這項交互作用的意義
Aprepitant and Lemborexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aprepitant belongs to Gastrointestinal Tract; Lemborexant belongs to Central Nervous System.
為什麼會發生
Aprepitant inhibits CYP3A4, reducing lemborexant clearance.
處置方式
Avoid combining where possible as labeling advises against moderate CYP3A inhibitors. If unavoidable, use the lowest lemborexant dose (5 mg) and counsel about next-day sedation.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Aprepitant 的其他交互作用
Lemborexant 的其他交互作用
常見問題
Can I take Aprepitant with Lemborexant?
MediHelp rates the interaction as major. Aprepitant and Lemborexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Aprepitant can raise lemborexant exposure through CYP3A4 inhibition. This may cause excess somnolence, next-day impairment and impaired driving ability.
How serious is the interaction between Aprepitant and Lemborexant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible as labeling advises against moderate CYP3A inhibitors. If unavoidable, use the lowest lemborexant dose (5 mg) and counsel about next-day sedation.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
