藥物交互作用
Chloramphenicol + Lemborexant
嚴重程度: 嚴重
Chloramphenicol and Lemborexant: major interaction.
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摘要
Lemborexant is metabolized mainly by CYP3A4, and inhibitors increase its exposure. This may cause excessive somnolence, next-day impairment and complex sleep behaviors.
用白話說明這項交互作用的意義
Chloramphenicol and Lemborexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Lemborexant belongs to Central Nervous System.
為什麼會發生
Chloramphenicol inhibits CYP3A4, reducing lemborexant clearance.
處置方式
Avoid the combination and consider another hypnotic or antibiotic. If lemborexant must continue, use the lowest dose and monitor for daytime sedation.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Chloramphenicol 的其他交互作用
Lemborexant 的其他交互作用
常見問題
Can I take Chloramphenicol with Lemborexant?
MediHelp rates the interaction as major. Chloramphenicol and Lemborexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lemborexant is metabolized mainly by CYP3A4, and inhibitors increase its exposure. This may cause excessive somnolence, next-day impairment and complex sleep behaviors.
How serious is the interaction between Chloramphenicol and Lemborexant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and consider another hypnotic or antibiotic. If lemborexant must continue, use the lowest dose and monitor for daytime sedation.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
