藥物交互作用
Amiodarone + Lemborexant
嚴重程度: 嚴重
Amiodarone and Lemborexant: major interaction.
最後更新
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摘要
Amiodarone can raise lemborexant exposure through CYP3A4 inhibition. Higher levels may cause excessive sedation, next-day somnolence and impaired psychomotor performance.
用白話說明這項交互作用的意義
Amiodarone and Lemborexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amiodarone belongs to Cardiovascular; Lemborexant belongs to Central Nervous System.
為什麼會發生
Amiodarone inhibits CYP3A4, reducing the metabolic clearance of lemborexant.
處置方式
Avoid the combination where possible; if used, keep lemborexant at the lowest recommended dose per labeling for CYP3A inhibitors and monitor for daytime sedation. Consider an alternative hypnotic not dependent on CYP3A4.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Amiodarone 的其他交互作用
Lemborexant 的其他交互作用
常見問題
Can I take Amiodarone with Lemborexant?
MediHelp rates the interaction as major. Amiodarone and Lemborexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amiodarone can raise lemborexant exposure through CYP3A4 inhibition. Higher levels may cause excessive sedation, next-day somnolence and impaired psychomotor performance.
How serious is the interaction between Amiodarone and Lemborexant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if used, keep lemborexant at the lowest recommended dose per labeling for CYP3A inhibitors and monitor for daytime sedation. Consider an alternative hypnotic not dependent on CYP3A4.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
