藥物交互作用
Carbamazepine + Lemborexant
嚴重程度: 嚴重
Carbamazepine and Lemborexant: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Strong CYP3A4 induction by carbamazepine substantially lowers lemborexant exposure, likely making it ineffective for insomnia.
用白話說明這項交互作用的意義
Carbamazepine and Lemborexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Lemborexant belongs to Central Nervous System.
為什麼會發生
Carbamazepine induces CYP3A4, which is the main pathway of lemborexant metabolism.
處置方式
Avoid co-use and consider another hypnotic not dependent on CYP3A4. Labeling advises against use with strong or moderate CYP3A inducers.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Carbamazepine 的其他交互作用
Lemborexant 的其他交互作用
常見問題
Can I take Carbamazepine with Lemborexant?
MediHelp rates the interaction as major. Carbamazepine and Lemborexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Strong CYP3A4 induction by carbamazepine substantially lowers lemborexant exposure, likely making it ineffective for insomnia.
How serious is the interaction between Carbamazepine and Lemborexant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid co-use and consider another hypnotic not dependent on CYP3A4. Labeling advises against use with strong or moderate CYP3A inducers.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
