藥物交互作用
Arsenic trioxide + Solifenacin
嚴重程度: 嚴重
Arsenic trioxide and Solifenacin: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Arsenic trioxide markedly prolongs the QT interval and can cause torsades de pointes. Solifenacin adds a further QT effect at higher exposures.
用白話說明這項交互作用的意義
Arsenic trioxide and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Arsenic trioxide belongs to Oncology; Solifenacin belongs to Genitourinary.
為什麼會發生
Additive prolongation of cardiac repolarization.
處置方式
Avoid solifenacin during arsenic trioxide therapy and use a non-QT-prolonging alternative. If it cannot be avoided, monitor ECG and keep electrolytes normal.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Solifenacin 的其他交互作用
Arsenic trioxide 的其他交互作用
常見問題
Can I take Arsenic trioxide with Solifenacin?
MediHelp rates the interaction as major. Arsenic trioxide and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Arsenic trioxide markedly prolongs the QT interval and can cause torsades de pointes. Solifenacin adds a further QT effect at higher exposures.
How serious is the interaction between Arsenic trioxide and Solifenacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid solifenacin during arsenic trioxide therapy and use a non-QT-prolonging alternative. If it cannot be avoided, monitor ECG and keep electrolytes normal.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
