藥物交互作用
Bedaquiline + Solifenacin
嚴重程度: 嚴重
Bedaquiline and Solifenacin: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Both drugs can prolong the QT interval, and combining them may increase the risk of torsades de pointes. The risk rises with electrolyte disturbances, bradycardia, heart disease or additional QT-prolonging drugs.
用白話說明這項交互作用的意義
Bedaquiline and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bedaquiline belongs to Anti Bacterial; Solifenacin belongs to Genitourinary.
為什麼會發生
Additive QT prolongation through cardiac repolarization effects.
處置方式
Obtain a baseline ECG and monitor it periodically, and correct potassium, magnesium and calcium; consider an alternative to solifenacin if QTc becomes prolonged.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Solifenacin 的其他交互作用
Bedaquiline 的其他交互作用
常見問題
Can I take Bedaquiline with Solifenacin?
MediHelp rates the interaction as major. Bedaquiline and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and combining them may increase the risk of torsades de pointes. The risk rises with electrolyte disturbances, bradycardia, heart disease or additional QT-prolonging drugs.
How serious is the interaction between Bedaquiline and Solifenacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it periodically, and correct potassium, magnesium and calcium; consider an alternative to solifenacin if QTc becomes prolonged.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
