藥物交互作用
Ceritinib + Solifenacin
嚴重程度: 嚴重
Ceritinib and Solifenacin: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Ceritinib prolongs the QT interval and inhibits CYP3A4, which raises solifenacin exposure. This increases the risk of QT-related arrhythmia.
用白話說明這項交互作用的意義
Ceritinib and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ceritinib belongs to Oncology; Solifenacin belongs to Genitourinary.
為什麼會發生
Additive QT prolongation plus CYP3A4 inhibition by ceritinib that raises solifenacin concentrations.
處置方式
Avoid the combination and choose another bladder agent. If it cannot be avoided, limit solifenacin to 5 mg daily and monitor ECG and electrolytes.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Solifenacin 的其他交互作用
Ceritinib 的其他交互作用
常見問題
Can I take Ceritinib with Solifenacin?
MediHelp rates the interaction as major. Ceritinib and Solifenacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ceritinib prolongs the QT interval and inhibits CYP3A4, which raises solifenacin exposure. This increases the risk of QT-related arrhythmia.
How serious is the interaction between Ceritinib and Solifenacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose another bladder agent. If it cannot be avoided, limit solifenacin to 5 mg daily and monitor ECG and electrolytes.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
