藥物交互作用
Atogepant + Clarithromycin
嚴重程度: 中度
Atogepant and Clarithromycin: moderate interaction.
最後更新
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摘要
Clarithromycin increases atogepant exposure, which may heighten adverse effects such as nausea, constipation and fatigue.
用白話說明這項交互作用的意義
Atogepant and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atogepant belongs to Central Nervous System; Clarithromycin belongs to Anti Bacterial.
為什麼會發生
Strong CYP3A4 inhibition (and possibly OATP/P-gp effects) reduces atogepant clearance.
處置方式
Limit atogepant to 10 mg once daily while clarithromycin is co-administered and monitor tolerability.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Clarithromycin 的其他交互作用
Atogepant 的其他交互作用
常見問題
Can I take Atogepant with Clarithromycin?
MediHelp rates the interaction as moderate. Atogepant and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin increases atogepant exposure, which may heighten adverse effects such as nausea, constipation and fatigue.
How serious is the interaction between Atogepant and Clarithromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit atogepant to 10 mg once daily while clarithromycin is co-administered and monitor tolerability.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
