藥物交互作用
Atorvastatin + Vadadustat
嚴重程度: 中度
Atorvastatin and Vadadustat: moderate interaction.
最後更新
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摘要
Vadadustat inhibits BCRP and can increase exposure to BCRP substrates such as atorvastatin. This may increase the risk of statin-related muscle adverse effects.
用白話說明這項交互作用的意義
Atorvastatin and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Vadadustat belongs to Endocrine.
為什麼會發生
Vadadustat inhibits breast cancer resistance protein (BCRP), reducing atorvastatin efflux and increasing its systemic exposure.
處置方式
Monitor for myalgia and consider reducing the atorvastatin dose if symptoms develop. Check creatine kinase when muscle symptoms occur.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Atorvastatin 的其他交互作用
Vadadustat 的其他交互作用
常見問題
Can I take Atorvastatin with Vadadustat?
MediHelp rates the interaction as moderate. Atorvastatin and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vadadustat inhibits BCRP and can increase exposure to BCRP substrates such as atorvastatin. This may increase the risk of statin-related muscle adverse effects.
How serious is the interaction between Atorvastatin and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for myalgia and consider reducing the atorvastatin dose if symptoms develop. Check creatine kinase when muscle symptoms occur.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
