藥物交互作用
Baricitinib + Vadadustat
嚴重程度: 中度
Baricitinib and Vadadustat: moderate interaction.
最後更新
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摘要
Vadadustat inhibits the organic anion transporter 3 (OAT3), which is a major route of renal elimination for baricitinib. Co-administration can raise baricitinib exposure and may increase dose-related adverse effects such as infection, cytopenias and lipid changes.
用白話說明這項交互作用的意義
Baricitinib and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baricitinib belongs to Musculoskeletal; Vadadustat belongs to Endocrine.
為什麼會發生
Vadadustat inhibits OAT3-mediated renal tubular secretion of baricitinib, reducing its clearance.
處置方式
Monitor for baricitinib adverse effects, including infections and blood counts. Consider baricitinib dose reduction according to its labeling for OAT3 inhibitors.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Baricitinib 的其他交互作用
Vadadustat 的其他交互作用
常見問題
Can I take Baricitinib with Vadadustat?
MediHelp rates the interaction as moderate. Baricitinib and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vadadustat inhibits the organic anion transporter 3 (OAT3), which is a major route of renal elimination for baricitinib. Co-administration can raise baricitinib exposure and may increase dose-related adverse effects such as infection, cytopenias and lipid changes.
How serious is the interaction between Baricitinib and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for baricitinib adverse effects, including infections and blood counts. Consider baricitinib dose reduction according to its labeling for OAT3 inhibitors.
What other medicines interact with Baricitinib?
MediHelp also lists interactions of Baricitinib with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Tofacitinib. The full list is on the Baricitinib page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
