藥物交互作用
Avanafil + Nelfinavir
嚴重程度: 禁忌併用
Avanafil and Nelfinavir: contraindicated interaction.
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摘要
Nelfinavir inhibits CYP3A4 and can significantly increase avanafil exposure. Severe hypotension, syncope, visual effects and priapism may follow.
用白話說明這項交互作用的意義
Avanafil and Nelfinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Avanafil belongs to Genitourinary; Nelfinavir belongs to Anti Virals.
為什麼會發生
CYP3A4 inhibition decreases avanafil metabolism.
處置方式
Do not coadminister; consider alternative therapy for erectile dysfunction.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Avanafil 的其他交互作用
Nelfinavir 的其他交互作用
常見問題
Can I take Avanafil with Nelfinavir?
MediHelp rates the interaction as contraindicated. Avanafil and Nelfinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nelfinavir inhibits CYP3A4 and can significantly increase avanafil exposure. Severe hypotension, syncope, visual effects and priapism may follow.
How serious is the interaction between Avanafil and Nelfinavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; consider alternative therapy for erectile dysfunction.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
