藥物交互作用
Eletriptan + Nelfinavir
嚴重程度: 禁忌併用
Eletriptan and Nelfinavir: contraindicated interaction.
最後更新
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摘要
Nelfinavir strongly inhibits CYP3A4 and increases eletriptan plasma levels. Greater exposure increases the risk of vasoconstrictive cardiovascular adverse effects.
用白話說明這項交互作用的意義
Eletriptan and Nelfinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Eletriptan belongs to Central Nervous System; Nelfinavir belongs to Anti Virals.
為什麼會發生
Inhibition of CYP3A4-mediated metabolism of eletriptan.
處置方式
Do not co-administer; avoid eletriptan for at least 72 hours after nelfinavir. Use an alternative triptan such as rizatriptan or sumatriptan.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Eletriptan 的其他交互作用
Nelfinavir 的其他交互作用
常見問題
Can I take Eletriptan with Nelfinavir?
MediHelp rates the interaction as contraindicated. Eletriptan and Nelfinavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Nelfinavir strongly inhibits CYP3A4 and increases eletriptan plasma levels. Greater exposure increases the risk of vasoconstrictive cardiovascular adverse effects.
How serious is the interaction between Eletriptan and Nelfinavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; avoid eletriptan for at least 72 hours after nelfinavir. Use an alternative triptan such as rizatriptan or sumatriptan.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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