藥物交互作用
Avanafil + Sapropterin
嚴重程度: 中度
Avanafil and Sapropterin: moderate interaction.
最後更新
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摘要
Sapropterin may increase nitric oxide synthesis, and combining it with a PDE5 inhibitor could enhance vasodilation and lower blood pressure. Clinically significant hypotension is possible but data are limited.
用白話說明這項交互作用的意義
Avanafil and Sapropterin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Sapropterin belongs to Miscellaneous.
為什麼會發生
Theoretical additive vasodilation via enhanced nitric oxide production and reduced cGMP breakdown.
處置方式
Monitor blood pressure and for dizziness when combining. Counsel the patient to report symptoms of hypotension.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Avanafil 的其他交互作用
Sapropterin 的其他交互作用
常見問題
Can I take Avanafil with Sapropterin?
MediHelp rates the interaction as moderate. Avanafil and Sapropterin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sapropterin may increase nitric oxide synthesis, and combining it with a PDE5 inhibitor could enhance vasodilation and lower blood pressure. Clinically significant hypotension is possible but data are limited.
How serious is the interaction between Avanafil and Sapropterin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for dizziness when combining. Counsel the patient to report symptoms of hypotension.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
