藥物交互作用
Carbidopa-entacapone-levodopa + Sapropterin
嚴重程度: 中度
Carbidopa-entacapone-levodopa and Sapropterin: moderate interaction.
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摘要
Sapropterin is a cofactor for tyrosine hydroxylase and nitric oxide synthase, and combined use with levodopa has been associated with reports of convulsions, overstimulation and irritability. Labeling advises caution, though evidence is limited.
用白話說明這項交互作用的意義
Carbidopa-entacapone-levodopa and Sapropterin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Sapropterin belongs to Miscellaneous.
為什麼會發生
Not firmly established; possibly enhanced dopaminergic and nitric oxide pathway activity.
處置方式
Monitor for agitation, irritability and seizures after starting sapropterin and reduce doses if these occur.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Carbidopa-entacapone-levodopa 的其他交互作用
- Carbidopa-entacapone-levodopa + Isocarboxazid 禁忌併用
- Carbidopa-entacapone-levodopa + Phenelzine 禁忌併用
- Carbidopa-entacapone-levodopa + Selegiline transdermal 禁忌併用
- Carbidopa-entacapone-levodopa + Tranylcypromine 禁忌併用
- Amisulpride + Carbidopa-entacapone-levodopa 嚴重
- Asenapine transdermal + Carbidopa-entacapone-levodopa 嚴重
Sapropterin 的其他交互作用
常見問題
Can I take Carbidopa-entacapone-levodopa with Sapropterin?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Sapropterin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sapropterin is a cofactor for tyrosine hydroxylase and nitric oxide synthase, and combined use with levodopa has been associated with reports of convulsions, overstimulation and irritability. Labeling advises caution, though evidence is limited.
How serious is the interaction between Carbidopa-entacapone-levodopa and Sapropterin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, irritability and seizures after starting sapropterin and reduce doses if these occur.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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