藥物交互作用
Levodopa + Sapropterin
嚴重程度: 中度
Levodopa and Sapropterin: moderate interaction.
最後更新
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摘要
Concomitant use has been associated with neurologic events such as seizures, exacerbated seizures, over-stimulation and irritability. The cause is not clearly established.
用白話說明這項交互作用的意義
Levodopa and Sapropterin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levodopa belongs to Central Nervous System; Sapropterin belongs to Miscellaneous.
為什麼會發生
Mechanism not established; possible effects on catecholamine neurotransmitter synthesis since sapropterin is a cofactor for tyrosine hydroxylase.
處置方式
Monitor neurologic status, including seizures and agitation, during combined use. Adjust the dose of either drug if events occur.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Sapropterin 的其他交互作用
Levodopa 的其他交互作用
常見問題
Can I take Levodopa with Sapropterin?
MediHelp rates the interaction as moderate. Levodopa and Sapropterin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concomitant use has been associated with neurologic events such as seizures, exacerbated seizures, over-stimulation and irritability. The cause is not clearly established.
How serious is the interaction between Levodopa and Sapropterin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neurologic status, including seizures and agitation, during combined use. Adjust the dose of either drug if events occur.
What other medicines interact with Sapropterin?
MediHelp also lists interactions of Sapropterin with, for example, Avanafil, Carbidopa-entacapone-levodopa, Carbidopa-levodopa. The full list is on the Sapropterin page.
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