藥物交互作用
Methotrexate + Sapropterin
嚴重程度: 中度
Methotrexate and Sapropterin: moderate interaction.
最後更新
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摘要
Methotrexate inhibits dihydrofolate reductase and may also inhibit dihydropteridine reductase, interfering with recycling of tetrahydrobiopterin. This may reduce sapropterin effect on phenylalanine control.
用白話說明這項交互作用的意義
Methotrexate and Sapropterin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Methotrexate belongs to Oncology; Sapropterin belongs to Miscellaneous.
為什麼會發生
Inhibition of folate and pteridine reductases by methotrexate impairs biopterin recycling.
處置方式
Monitor blood phenylalanine levels when starting or stopping methotrexate. Adjust sapropterin dose according to response.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Methotrexate 的其他交互作用
Sapropterin 的其他交互作用
常見問題
Can I take Methotrexate with Sapropterin?
MediHelp rates the interaction as moderate. Methotrexate and Sapropterin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methotrexate inhibits dihydrofolate reductase and may also inhibit dihydropteridine reductase, interfering with recycling of tetrahydrobiopterin. This may reduce sapropterin effect on phenylalanine control.
How serious is the interaction between Methotrexate and Sapropterin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood phenylalanine levels when starting or stopping methotrexate. Adjust sapropterin dose according to response.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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