藥物交互作用
Cefoxitin + Gentamicin
嚴重程度: 中度
Cefoxitin and Gentamicin: moderate interaction.
最後更新
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摘要
Concurrent use of a cephalosporin with an aminoglycoside has been associated with additive kidney injury in some reports, particularly in patients with other risk factors. Aminoglycoside ototoxicity may also be a concern with prolonged exposure. The effect is generally manageable.
用白話說明這項交互作用的意義
Cefoxitin and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefoxitin belongs to Anti Bacterial; Gentamicin belongs to Anti Bacterial.
為什麼會發生
Additive nephrotoxic potential, with aminoglycoside tubular toxicity possibly being aggravated by cephalosporins.
處置方式
Monitor serum creatinine and gentamicin trough levels during combined therapy, and keep the aminoglycoside course as short as possible. Ensure adequate hydration and avoid other nephrotoxins.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Cefoxitin 的其他交互作用
Gentamicin 的其他交互作用
常見問題
Can I take Cefoxitin with Gentamicin?
MediHelp rates the interaction as moderate. Cefoxitin and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use of a cephalosporin with an aminoglycoside has been associated with additive kidney injury in some reports, particularly in patients with other risk factors. Aminoglycoside ototoxicity may also be a concern with prolonged exposure. The effect is generally manageable.
How serious is the interaction between Cefoxitin and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and gentamicin trough levels during combined therapy, and keep the aminoglycoside course as short as possible. Ensure adequate hydration and avoid other nephrotoxins.
What other medicines interact with Cefoxitin?
MediHelp also lists interactions of Cefoxitin with, for example, Amikacin, Aztreonam, Bcg vaccine live. The full list is on the Cefoxitin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
