藥物交互作用
Bcg intravesical live + Certolizumab pegol
嚴重程度: 禁忌併用
Bcg intravesical live and Certolizumab pegol: contraindicated interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Intravesical BCG is live Mycobacterium bovis. In patients on a TNF inhibitor, impaired granulomatous immunity may permit systemic BCG infection (BCGosis), and the antitumor response may be reduced.
用白話說明這項交互作用的意義
Bcg intravesical live and Certolizumab pegol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
為什麼會發生
TNF is essential for granuloma formation and mycobacterial containment, so its inhibition allows BCG dissemination.
處置方式
Avoid intravesical BCG during certolizumab therapy and consider alternative bladder cancer treatment. If BCG is essential, discuss pausing certolizumab with the treating specialists.
可向藥師詢問的問題
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Certolizumab pegol 的其他交互作用
- Adenovirus types 4 and 7 live + Certolizumab pegol 禁忌併用
- Bcg vaccine live + Certolizumab pegol 禁忌併用
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal 禁忌併用
- Certolizumab pegol + Measles mumps and rubella vaccine 禁忌併用
- Certolizumab pegol + Measles mumps and rubella vaccine live 禁忌併用
- Certolizumab pegol + Measles mumps rubella and varicella vaccine live 禁忌併用
常見問題
Can I take Bcg intravesical live with Certolizumab pegol?
MediHelp rates the interaction as contraindicated. Bcg intravesical live and Certolizumab pegol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Intravesical BCG is live Mycobacterium bovis. In patients on a TNF inhibitor, impaired granulomatous immunity may permit systemic BCG infection (BCGosis), and the antitumor response may be reduced.
How serious is the interaction between Bcg intravesical live and Certolizumab pegol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid intravesical BCG during certolizumab therapy and consider alternative bladder cancer treatment. If BCG is essential, discuss pausing certolizumab with the treating specialists.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Certolizumab pegol page.
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