藥品參考
Certolizumab pegol
Certolizumab pegol is a medicine in the class musculoskeletal. It is used for ankylosing spondylitis.
- 藥物類別: Musculoskeletal
- 用途: ankylosing spondylitis
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
重點資訊
- 藥物類別
- Musculoskeletal
- ATC 代碼
- L04AB05
- 常見劑型
- 注射劑
- 常見規格
- 200 mg, 200 mg/ml
- 已知交互作用
- 83 (禁忌併用: 13 · 嚴重: 25 · 中度: 22 · 輕微: 23)
- 商品名
- 5
- 國家與市場
- 5
用途
作用方式
Recombinant humanized antihuman TNF-alpha neutralizing antibody Binds to human TNFα with a KD of 90pM; TNF-alpha is a key pro-inflammatory cytokine with a central role in inflammatory processes
成人常用劑量（仿單摘要）
Crohn Disease (Initial): 400 mg SC (2 injections of 200 mg), repeat at 2 and 4 weeks
懷孕與哺乳
- 懷孕
- Safe Very little crosses the placenta (no Fc region). Data from over 1,500 first-trimester exposures show no rise in birth defects. One of the preferred TNF blockers in pregnancy; can be continued if needed. EU label: delay live vaccines (e.g. BCG) in an exposed infant for 5 months.
- 哺乳
- Safe Milk levels are minimal (CRADLE study) and it is poorly absorbed by the infant. Compatible with breastfeeding.
已通報的副作用
- Headache
- Nasopharyngitis
- URI
- Arthralgia
- Serious infections
禁忌症
- History of hypersensitivity reaction to certolizumab pegol or to any of the excipients; reactions have included angioedema, anaphylactoid reaction, serum sickness, and urticaria
哪些人需要特別留意
- Increased risk for developing serious infections resulting in hospitalization or death; most patients were taking concomitant immunosuppressants (eg, methotrexate)
- Lymphoma and other malignancies, some fatal, have been reported in children and adolescents treated with TNF blockers.
- Should not receive any live or attenuated vaccines.
請告知藥師或醫師您是否懷孕或哺乳、是否患有腎臟或肝臟疾病、是否有過敏，以及您正在使用的所有其他藥物或保健品。
重要交互作用 (83)
- Adenovirus types 4 and 7 live + Certolizumab pegol Contraindicated
- Bcg intravesical live + Certolizumab pegol Contraindicated
- Bcg vaccine live + Certolizumab pegol Contraindicated
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine live Contraindicated
- Certolizumab pegol + Measles mumps rubella and varicella vaccine live Contraindicated
- Certolizumab pegol + Rotavirus oral vaccine live Contraindicated
- Certolizumab pegol + Smallpox vaccine live Contraindicated
- Certolizumab pegol + Typhoid vaccine live Contraindicated
同類別的其他藥品
常見問題
What is Certolizumab pegol used for?
Certolizumab pegol is a medicine in the class musculoskeletal. It is used for Ankylosing spondylitis, Crohn's disease, Psoriasis, Rheumatoid arthritis, Spondyloarthritis.
What side effects have been reported with Certolizumab pegol?
Headache, Nasopharyngitis, URI, Arthralgia, Serious infections.
Can Certolizumab pegol be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. Very little crosses the placenta (no Fc region). Data from over 1,500 first-trimester exposures show no rise in birth defects. One of the preferred TNF blockers in pregnancy; can be continued if needed. EU label: delay live vaccines (e.g. BCG) in an exposed infant for 5 months. Breastfeeding: Safe. Milk levels are minimal (CRADLE study) and it is poorly absorbed by the infant. Compatible with breastfeeding.
What does Certolizumab pegol interact with?
MediHelp lists 83 known interactions for Certolizumab pegol. Contraindicated: 13 · Major: 25 · Moderate: 22 · Minor: 23. The most serious include Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
