藥物交互作用
Benzathine penicillin g + Ceftobiprole medocaril
嚴重程度: 輕微
Benzathine penicillin g and Ceftobiprole medocaril: minor interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Ceftobiprole inhibits hepatic uptake transporters OATP1B1 and OATP1B3 and could raise exposure to substrates. Penicillin G is not a clinically important OATP substrate and has a wide therapeutic index, so a meaningful effect is not expected.
用白話說明這項交互作用的意義
Benzathine penicillin g and Ceftobiprole medocaril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
為什麼會發生
Possible inhibition of OATP1B1/1B3-mediated uptake by ceftobiprole; relevance for penicillin G is theoretical.
處置方式
No dose adjustment is needed. Be aware of the potential effect and watch for penicillin adverse effects such as hypersensitivity or neurotoxicity in patients with renal impairment.
可向藥師詢問的問題
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Benzathine penicillin g 的其他交互作用
常見問題
Can I take Benzathine penicillin g with Ceftobiprole medocaril?
MediHelp rates the interaction as minor. Benzathine penicillin g and Ceftobiprole medocaril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ceftobiprole inhibits hepatic uptake transporters OATP1B1 and OATP1B3 and could raise exposure to substrates. Penicillin G is not a clinically important OATP substrate and has a wide therapeutic index, so a meaningful effect is not expected.
How serious is the interaction between Benzathine penicillin g and Ceftobiprole medocaril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Be aware of the potential effect and watch for penicillin adverse effects such as hypersensitivity or neurotoxicity in patients with renal impairment.
What other medicines interact with Benzathine penicillin g?
MediHelp also lists interactions of Benzathine penicillin g with, for example, Cholera vaccine, Microbiota, Omadacycline. The full list is on the Benzathine penicillin g page.
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