藥物交互作用
Berotralstat + Nilotinib
嚴重程度: 嚴重
Berotralstat and Nilotinib: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Berotralstat inhibits P-glycoprotein and can raise concentrations of nilotinib, which is a P-gp substrate. It also inhibits CYP3A4 and prolongs QT at higher doses, so nilotinib toxicity including QT prolongation may increase.
用白話說明這項交互作用的意義
Berotralstat and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Berotralstat belongs to Miscellaneous; Nilotinib belongs to Oncology.
為什麼會發生
Inhibition of P-gp and CYP3A4 by berotralstat increases nilotinib exposure, with additive QT effects.
處置方式
Obtain a baseline ECG and monitor it, along with electrolytes, during coadministration. Consider an alternative HAE prophylaxis if QTc increases.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Nilotinib 的其他交互作用
Berotralstat 的其他交互作用
常見問題
Can I take Berotralstat with Nilotinib?
MediHelp rates the interaction as major. Berotralstat and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Berotralstat inhibits P-glycoprotein and can raise concentrations of nilotinib, which is a P-gp substrate. It also inhibits CYP3A4 and prolongs QT at higher doses, so nilotinib toxicity including QT prolongation may increase.
How serious is the interaction between Berotralstat and Nilotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it, along with electrolytes, during coadministration. Consider an alternative HAE prophylaxis if QTc increases.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
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