藥物交互作用
Berotralstat + Quinine
嚴重程度: 嚴重
Berotralstat and Quinine: major interaction.
最後更新
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摘要
Berotralstat inhibits CYP3A4 and P-glycoprotein, both of which affect quinine clearance, so quinine levels may rise. Berotralstat itself also prolongs the QT interval at higher doses, and quinine is a P-gp inhibitor that may raise berotralstat levels.
用白話說明這項交互作用的意義
Berotralstat and Quinine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Berotralstat belongs to Miscellaneous; Quinine belongs to Anti Parasitic.
為什麼會發生
Inhibition of CYP3A4 and P-glycoprotein by berotralstat reduces quinine clearance, with additive QT effects.
處置方式
Avoid if possible because of the QT risk. If required, obtain an ECG, monitor for quinine toxicity such as cinchonism, and correct electrolytes.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Quinine 的其他交互作用
Berotralstat 的其他交互作用
常見問題
Can I take Berotralstat with Quinine?
MediHelp rates the interaction as major. Berotralstat and Quinine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Berotralstat inhibits CYP3A4 and P-glycoprotein, both of which affect quinine clearance, so quinine levels may rise. Berotralstat itself also prolongs the QT interval at higher doses, and quinine is a P-gp inhibitor that may raise berotralstat levels.
How serious is the interaction between Berotralstat and Quinine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible because of the QT risk. If required, obtain an ECG, monitor for quinine toxicity such as cinchonism, and correct electrolytes.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
