藥物交互作用
Berotralstat + Quinidine
嚴重程度: 嚴重
Berotralstat and Quinidine: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Berotralstat inhibits P-gp and CYP3A4, both involved in quinidine disposition, and can increase quinidine levels. Quinidine may also raise berotralstat via P-gp inhibition. Elevated quinidine exposure increases the risk of QT prolongation and arrhythmia, and berotralstat itself prolongs QT at higher doses.
用白話說明這項交互作用的意義
Berotralstat and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Berotralstat belongs to Miscellaneous; Quinidine belongs to Anti Parasitic.
為什麼會發生
Berotralstat inhibits P-gp and CYP3A4, reducing quinidine clearance, while quinidine inhibits P-gp efflux of berotralstat.
處置方式
Monitor ECG QTc and quinidine concentrations, and reduce the quinidine dose if levels or QTc rise; consider an alternative antiarrhythmic.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Quinidine 的其他交互作用
Berotralstat 的其他交互作用
常見問題
Can I take Berotralstat with Quinidine?
MediHelp rates the interaction as major. Berotralstat and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Berotralstat inhibits P-gp and CYP3A4, both involved in quinidine disposition, and can increase quinidine levels. Quinidine may also raise berotralstat via P-gp inhibition. Elevated quinidine exposure increases the risk of QT prolongation and arrhythmia, and berotralstat itself prolongs QT at higher doses.
How serious is the interaction between Berotralstat and Quinidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG QTc and quinidine concentrations, and reduce the quinidine dose if levels or QTc rise; consider an alternative antiarrhythmic.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
