藥物交互作用
Bismuth subsalicylate + Oxytetracycline
嚴重程度: 中度
Bismuth subsalicylate and Oxytetracycline: moderate interaction.
最後更新
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摘要
Bismuth in oral bismuth subsalicylate can bind oxytetracycline in the gut and reduce its absorption. This may lead to lower antibiotic levels and treatment failure.
用白話說明這項交互作用的意義
Bismuth subsalicylate and Oxytetracycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bismuth subsalicylate belongs to Gastrointestinal Tract; Oxytetracycline belongs to Anti Bacterial.
為什麼會發生
Chelation of oxytetracycline by bismuth in the gastrointestinal tract reduces absorption.
處置方式
Separate doses by at least 2 to 3 hours, giving oxytetracycline first, or use an alternative if separation is not feasible.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Bismuth subsalicylate 的其他交互作用
Oxytetracycline 的其他交互作用
常見問題
Can I take Bismuth subsalicylate with Oxytetracycline?
MediHelp rates the interaction as moderate. Bismuth subsalicylate and Oxytetracycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bismuth in oral bismuth subsalicylate can bind oxytetracycline in the gut and reduce its absorption. This may lead to lower antibiotic levels and treatment failure.
How serious is the interaction between Bismuth subsalicylate and Oxytetracycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate doses by at least 2 to 3 hours, giving oxytetracycline first, or use an alternative if separation is not feasible.
What other medicines interact with Bismuth subsalicylate?
MediHelp also lists interactions of Bismuth subsalicylate with, for example, Dichlorphenamide, Warfarin, Acetylsalicylic acid. The full list is on the Bismuth subsalicylate page.
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