藥物交互作用
Bortezomib + Idelalisib
嚴重程度: 嚴重
Bortezomib and Idelalisib: major interaction.
最後更新 來源: US FDA label
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摘要
Idelalisib is a strong CYP3A inhibitor, and bortezomib is partly cleared by CYP3A4. Strong inhibitors such as ketoconazole have increased bortezomib exposure, so toxicity such as neuropathy and thrombocytopenia may rise. Idelalisib also carries risks of serious infection and diarrhea.
用白話說明這項交互作用的意義
Bortezomib and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bortezomib belongs to Oncology; Idelalisib belongs to Oncology.
為什麼會發生
Idelalisib inhibits CYP3A4, reducing bortezomib clearance.
處置方式
Monitor closely for neuropathy, cytopenias and infection, and consider a bortezomib dose reduction. Choose an alternative to idelalisib if possible.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
Bortezomib 的其他交互作用
Idelalisib 的其他交互作用
常見問題
Can I take Bortezomib with Idelalisib?
MediHelp rates the interaction as major. Bortezomib and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Idelalisib is a strong CYP3A inhibitor, and bortezomib is partly cleared by CYP3A4. Strong inhibitors such as ketoconazole have increased bortezomib exposure, so toxicity such as neuropathy and thrombocytopenia may rise. Idelalisib also carries risks of serious infection and diarrhea.
How serious is the interaction between Bortezomib and Idelalisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for neuropathy, cytopenias and infection, and consider a bortezomib dose reduction. Choose an alternative to idelalisib if possible.
What other medicines interact with Bortezomib?
MediHelp also lists interactions of Bortezomib with, for example, Apalutamide, Carbamazepine, Etrasimod. The full list is on the Bortezomib page.
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