藥物交互作用
Bortezomib + Carbamazepine
嚴重程度: 嚴重
Bortezomib and Carbamazepine: major interaction.
最後更新 來源: EMA SmPC
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本頁的臨床內容僅提供英文版。
摘要
Strong CYP3A4 inducers lower bortezomib exposure, which may reduce its efficacy. Carbamazepine is a strong inducer.
用白話說明這項交互作用的意義
Bortezomib and Carbamazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bortezomib belongs to Oncology; Carbamazepine belongs to Central Nervous System.
為什麼會發生
Carbamazepine induces CYP3A4, increasing bortezomib clearance.
處置方式
Avoid concurrent use if possible and switch to a non-inducing antiseizure drug. If unavoidable, monitor disease response.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
Carbamazepine 的其他交互作用
Bortezomib 的其他交互作用
常見問題
Can I take Bortezomib with Carbamazepine?
MediHelp rates the interaction as major. Bortezomib and Carbamazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Strong CYP3A4 inducers lower bortezomib exposure, which may reduce its efficacy. Carbamazepine is a strong inducer.
How serious is the interaction between Bortezomib and Carbamazepine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if possible and switch to a non-inducing antiseizure drug. If unavoidable, monitor disease response.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
