藥物交互作用
Apalutamide + Bortezomib
嚴重程度: 嚴重
Apalutamide and Bortezomib: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Apalutamide may reduce bortezomib exposure through induction of CYP3A4 and CYP2C19, potentially weakening antimyeloma activity.
用白話說明這項交互作用的意義
Apalutamide and Bortezomib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Bortezomib belongs to Oncology.
為什麼會發生
Induction of CYP3A4 and CYP2C19 increases bortezomib metabolism.
處置方式
Avoid combination with strong CYP3A4 inducers when possible and monitor for reduced response if coadministered.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Apalutamide 的其他交互作用
Bortezomib 的其他交互作用
常見問題
Can I take Apalutamide with Bortezomib?
MediHelp rates the interaction as major. Apalutamide and Bortezomib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide may reduce bortezomib exposure through induction of CYP3A4 and CYP2C19, potentially weakening antimyeloma activity.
How serious is the interaction between Apalutamide and Bortezomib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination with strong CYP3A4 inducers when possible and monitor for reduced response if coadministered.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
