藥物交互作用
Bortezomib + Lonafarnib
嚴重程度: 嚴重
Bortezomib and Lonafarnib: major interaction.
最後更新 來源: US FDA label
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Lonafarnib is a strong CYP3A inhibitor and may increase bortezomib exposure, worsening neuropathy and cytopenias. Lonafarnib is itself a sensitive CYP3A substrate, so inhibition by bortezomib is unlikely to be clinically relevant. Lonafarnib's QT effect is also unknown.
用白話說明這項交互作用的意義
Bortezomib and Lonafarnib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bortezomib belongs to Oncology; Lonafarnib belongs to Miscellaneous.
為什麼會發生
Lonafarnib inhibits CYP3A4, decreasing bortezomib clearance.
處置方式
Avoid if possible; otherwise monitor for neuropathy, thrombocytopenia and arrhythmia symptoms, and consider reducing the bortezomib dose.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
參考資料
Bortezomib 的其他交互作用
Lonafarnib 的其他交互作用
常見問題
Can I take Bortezomib with Lonafarnib?
MediHelp rates the interaction as major. Bortezomib and Lonafarnib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lonafarnib is a strong CYP3A inhibitor and may increase bortezomib exposure, worsening neuropathy and cytopenias. Lonafarnib is itself a sensitive CYP3A substrate, so inhibition by bortezomib is unlikely to be clinically relevant. Lonafarnib's QT effect is also unknown.
How serious is the interaction between Bortezomib and Lonafarnib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise monitor for neuropathy, thrombocytopenia and arrhythmia symptoms, and consider reducing the bortezomib dose.
What other medicines interact with Bortezomib?
MediHelp also lists interactions of Bortezomib with, for example, Apalutamide, Carbamazepine, Etrasimod. The full list is on the Bortezomib page.
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