藥物交互作用
Bosentan + Paricalcitol
嚴重程度: 輕微
Bosentan and Paricalcitol: minor interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Bosentan may modestly lower paricalcitol exposure through CYP3A4 induction. The effect on parathyroid hormone suppression is likely small but could reduce efficacy.
用白話說明這項交互作用的意義
Bosentan and Paricalcitol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosentan belongs to Miscellaneous; Paricalcitol belongs to Musculoskeletal.
為什麼會發生
Bosentan induces CYP3A4, increasing the metabolism of paricalcitol.
處置方式
Monitor intact PTH and serum calcium and phosphate after starting or stopping bosentan. Adjust the paricalcitol dose according to these results.
可向藥師詢問的問題
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Bosentan 的其他交互作用
Paricalcitol 的其他交互作用
常見問題
Can I take Bosentan with Paricalcitol?
MediHelp rates the interaction as minor. Bosentan and Paricalcitol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosentan may modestly lower paricalcitol exposure through CYP3A4 induction. The effect on parathyroid hormone suppression is likely small but could reduce efficacy.
How serious is the interaction between Bosentan and Paricalcitol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor intact PTH and serum calcium and phosphate after starting or stopping bosentan. Adjust the paricalcitol dose according to these results.
What other medicines interact with Bosentan?
MediHelp also lists interactions of Bosentan with, for example, Cyclosporin, Cyclosporine, Glyburide. The full list is on the Bosentan page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
