藥物交互作用
Buprenorphine + Chlordiazepoxide-clidinium
嚴重程度: 嚴重
Buprenorphine and Chlordiazepoxide-clidinium: major interaction.
最後更新
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摘要
Benzodiazepines combined with opioids such as buprenorphine can cause profound sedation, respiratory depression, coma and death. Regulators have issued boxed warnings for this class combination.
用白話說明這項交互作用的意義
Buprenorphine and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Buprenorphine belongs to Musculoskeletal; Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract.
為什麼會發生
Additive CNS and respiratory depression via opioid and GABA-A receptor effects.
處置方式
Avoid the combination when possible; if necessary, use the lowest doses for the shortest duration. Monitor respiratory rate and sedation and counsel patients and caregivers about warning signs.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Chlordiazepoxide-clidinium 的其他交互作用
Buprenorphine 的其他交互作用
常見問題
Can I take Buprenorphine with Chlordiazepoxide-clidinium?
MediHelp rates the interaction as major. Buprenorphine and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benzodiazepines combined with opioids such as buprenorphine can cause profound sedation, respiratory depression, coma and death. Regulators have issued boxed warnings for this class combination.
How serious is the interaction between Buprenorphine and Chlordiazepoxide-clidinium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible; if necessary, use the lowest doses for the shortest duration. Monitor respiratory rate and sedation and counsel patients and caregivers about warning signs.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
