藥物交互作用
Cabazitaxel + Miconazole
嚴重程度: 嚴重
Cabazitaxel and Miconazole: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Systemic miconazole inhibits CYP3A4 and may substantially raise cabazitaxel exposure, increasing the risk of severe neutropenia. Topical or buccal use produces less systemic effect, but oral gel can still be absorbed.
用白話說明這項交互作用的意義
Cabazitaxel and Miconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cabazitaxel belongs to Oncology; Miconazole belongs to Anti Fungals.
為什麼會發生
Miconazole inhibits CYP3A4, reducing cabazitaxel metabolism.
處置方式
Avoid systemic miconazole, using a non-inhibiting antifungal; if unavoidable, monitor blood counts closely and consider reducing the cabazitaxel dose.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Cabazitaxel 的其他交互作用
Miconazole 的其他交互作用
常見問題
Can I take Cabazitaxel with Miconazole?
MediHelp rates the interaction as major. Cabazitaxel and Miconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Systemic miconazole inhibits CYP3A4 and may substantially raise cabazitaxel exposure, increasing the risk of severe neutropenia. Topical or buccal use produces less systemic effect, but oral gel can still be absorbed.
How serious is the interaction between Cabazitaxel and Miconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic miconazole, using a non-inhibiting antifungal; if unavoidable, monitor blood counts closely and consider reducing the cabazitaxel dose.
What other medicines interact with Cabazitaxel?
MediHelp also lists interactions of Cabazitaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Bcg intravesical live. The full list is on the Cabazitaxel page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
