藥物交互作用
Glyburide + Miconazole
嚴重程度: 嚴重
Glyburide and Miconazole: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Glyburide is metabolized by CYP2C9 and CYP3A4, both inhibited by miconazole. Increased levels can cause severe and prolonged hypoglycemia, and cases have been reported with miconazole. The risk is greater in elderly patients and those with renal impairment.
用白話說明這項交互作用的意義
Glyburide and Miconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Glyburide belongs to Endocrine; Miconazole belongs to Anti Fungals.
為什麼會發生
Miconazole inhibits CYP2C9 and CYP3A4, reducing glyburide clearance.
處置方式
Monitor blood glucose frequently and counsel on hypoglycemia symptoms. Reduce the glyburide dose or switch to a non-azole antifungal or alternative agent if feasible.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Miconazole 的其他交互作用
Glyburide 的其他交互作用
常見問題
Can I take Glyburide with Miconazole?
MediHelp rates the interaction as major. Glyburide and Miconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Glyburide is metabolized by CYP2C9 and CYP3A4, both inhibited by miconazole. Increased levels can cause severe and prolonged hypoglycemia, and cases have been reported with miconazole. The risk is greater in elderly patients and those with renal impairment.
How serious is the interaction between Glyburide and Miconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently and counsel on hypoglycemia symptoms. Reduce the glyburide dose or switch to a non-azole antifungal or alternative agent if feasible.
What other medicines interact with Miconazole?
MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Miconazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
