藥物交互作用
Ergotamine + Miconazole
嚴重程度: 嚴重
Ergotamine and Miconazole: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Miconazole is a CYP3A4 inhibitor, but only oral-gel or systemic dosing yields meaningful exposure; vaginal or topical use is minimally absorbed. With systemic exposure, ergotamine levels can rise and cause vasospasm.
用白話說明這項交互作用的意義
Ergotamine and Miconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ergotamine belongs to Central Nervous System; Miconazole belongs to Anti Fungals.
為什麼會發生
CYP3A4 inhibition raising ergotamine exposure (clinically relevant with systemic miconazole)
處置方式
Avoid with systemic or buccal miconazole; topical and vaginal use carries little risk.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Miconazole 的其他交互作用
Ergotamine 的其他交互作用
常見問題
Can I take Ergotamine with Miconazole?
MediHelp rates the interaction as major. Ergotamine and Miconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Miconazole is a CYP3A4 inhibitor, but only oral-gel or systemic dosing yields meaningful exposure; vaginal or topical use is minimally absorbed. With systemic exposure, ergotamine levels can rise and cause vasospasm.
How serious is the interaction between Ergotamine and Miconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid with systemic or buccal miconazole; topical and vaginal use carries little risk.
What other medicines interact with Miconazole?
MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Miconazole page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
