藥物交互作用
Carbamazepine + Dapsone
嚴重程度: 中度
Carbamazepine and Dapsone: moderate interaction.
最後更新
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摘要
Carbamazepine induces CYP3A4 and may lower dapsone concentrations, potentially reducing efficacy. Induction may also increase formation of dapsone hydroxylamine, which can worsen haemolysis and methaemoglobinaemia.
用白話說明這項交互作用的意義
Carbamazepine and Dapsone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Dapsone belongs to Anti Bacterial.
為什麼會發生
CYP3A4 induction by carbamazepine increases dapsone metabolism, including N-hydroxylation.
處置方式
Monitor clinical response, haemoglobin and methaemoglobin levels, and increase monitoring frequency after carbamazepine starts or stops.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Dapsone 的其他交互作用
Carbamazepine 的其他交互作用
常見問題
Can I take Carbamazepine with Dapsone?
MediHelp rates the interaction as moderate. Carbamazepine and Dapsone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine induces CYP3A4 and may lower dapsone concentrations, potentially reducing efficacy. Induction may also increase formation of dapsone hydroxylamine, which can worsen haemolysis and methaemoglobinaemia.
How serious is the interaction between Carbamazepine and Dapsone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response, haemoglobin and methaemoglobin levels, and increase monitoring frequency after carbamazepine starts or stops.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
