藥物交互作用
Carbidopa-entacapone-levodopa + Ferric maltol
嚴重程度: 中度
Carbidopa-entacapone-levodopa and Ferric maltol: moderate interaction.
最後更新
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摘要
Oral iron binds levodopa and entacapone in the gut, forming chelates that reduce absorption. This can lessen levodopa effect and lead to worsening of Parkinson symptoms. Entacapone also chelates iron, which may reduce iron uptake.
用白話說明這項交互作用的意義
Carbidopa-entacapone-levodopa and Ferric maltol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Ferric maltol belongs to Miscellaneous.
為什麼會發生
Chelation of levodopa and entacapone by ferric iron in the gastrointestinal tract reduces absorption.
處置方式
Separate oral ferric maltol from the levodopa combination by at least 2 hours. Monitor motor symptoms and iron indices.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Carbidopa-entacapone-levodopa 的其他交互作用
- Carbidopa-entacapone-levodopa + Isocarboxazid 禁忌併用
- Carbidopa-entacapone-levodopa + Phenelzine 禁忌併用
- Carbidopa-entacapone-levodopa + Selegiline transdermal 禁忌併用
- Carbidopa-entacapone-levodopa + Tranylcypromine 禁忌併用
- Amisulpride + Carbidopa-entacapone-levodopa 嚴重
- Asenapine transdermal + Carbidopa-entacapone-levodopa 嚴重
Ferric maltol 的其他交互作用
常見問題
Can I take Carbidopa-entacapone-levodopa with Ferric maltol?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Ferric maltol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral iron binds levodopa and entacapone in the gut, forming chelates that reduce absorption. This can lessen levodopa effect and lead to worsening of Parkinson symptoms. Entacapone also chelates iron, which may reduce iron uptake.
How serious is the interaction between Carbidopa-entacapone-levodopa and Ferric maltol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate oral ferric maltol from the levodopa combination by at least 2 hours. Monitor motor symptoms and iron indices.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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