藥物交互作用
Magnesium hydroxide + Raltegravir
嚴重程度: 嚴重
Magnesium hydroxide and Raltegravir: major interaction.
最後更新
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摘要
Magnesium-containing antacids bind raltegravir in the gut and can reduce its plasma concentrations. Lower exposure may risk virologic failure and resistance, particularly with the once-daily 1200 mg regimen.
用白話說明這項交互作用的意義
Magnesium hydroxide and Raltegravir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Magnesium hydroxide belongs to Gastrointestinal Tract; Raltegravir belongs to Anti Virals.
為什麼會發生
Chelation of raltegravir by magnesium cations in the gastrointestinal tract reduces absorption.
處置方式
Avoid concomitant use with magnesium-containing antacids; if unavoidable, separate dosing by at least 6 hours. Use a non-cation acid suppressant alternative if possible.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Magnesium hydroxide 的其他交互作用
Raltegravir 的其他交互作用
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Raltegravir 禁忌併用
- Aluminum hydroxide / magnesium carbonate + Raltegravir 嚴重
- Aluminum hydroxide / magnesium trisilicate + Raltegravir 嚴重
- Aluminum hydroxide + Raltegravir 嚴重
- Atidarsagene autotemcel + Raltegravir 嚴重
- Betibeglogene autotemcel + Raltegravir 嚴重
常見問題
Can I take Magnesium hydroxide with Raltegravir?
MediHelp rates the interaction as major. Magnesium hydroxide and Raltegravir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Magnesium-containing antacids bind raltegravir in the gut and can reduce its plasma concentrations. Lower exposure may risk virologic failure and resistance, particularly with the once-daily 1200 mg regimen.
How serious is the interaction between Magnesium hydroxide and Raltegravir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use with magnesium-containing antacids; if unavoidable, separate dosing by at least 6 hours. Use a non-cation acid suppressant alternative if possible.
What other medicines interact with Magnesium hydroxide?
MediHelp also lists interactions of Magnesium hydroxide with, for example, Ciprofloxacin, Dolutegravir, Gemifloxacin. The full list is on the Magnesium hydroxide page.
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