藥物交互作用
Clomipramine + Pefloxacin
嚴重程度: 中度
Clomipramine and Pefloxacin: moderate interaction.
最後更新
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摘要
Pefloxacin inhibits CYP1A2, one of the pathways metabolising clomipramine, so levels may rise and cause tricyclic adverse effects. Fluoroquinolones can also prolong the QT interval and lower the seizure threshold.
用白話說明這項交互作用的意義
Clomipramine and Pefloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Pefloxacin belongs to Anti Bacterial.
為什麼會發生
CYP1A2 inhibition by pefloxacin reduces clomipramine clearance, with additive QT and seizure-threshold effects.
處置方式
Monitor for anticholinergic, cardiac and neurological toxicity and consider an ECG; choose a non-quinolone antibiotic if possible.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Clomipramine 的其他交互作用
Pefloxacin 的其他交互作用
常見問題
Can I take Clomipramine with Pefloxacin?
MediHelp rates the interaction as moderate. Clomipramine and Pefloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pefloxacin inhibits CYP1A2, one of the pathways metabolising clomipramine, so levels may rise and cause tricyclic adverse effects. Fluoroquinolones can also prolong the QT interval and lower the seizure threshold.
How serious is the interaction between Clomipramine and Pefloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic, cardiac and neurological toxicity and consider an ECG; choose a non-quinolone antibiotic if possible.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
