跳至主要內容
MediHelp
MediHelp 藥品參考

藥物交互作用

Cobicistat + Dapsone

嚴重程度: 中度

Cobicistat and Dapsone: moderate interaction.

最後更新

僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

摘要

Cobicistat is a strong CYP3A4 inhibitor and may increase dapsone exposure. Higher dapsone levels could raise the risk of dose-related hemolysis and methemoglobinemia.

用白話說明這項交互作用的意義

Cobicistat and Dapsone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Cobicistat belongs to Miscellaneous; Dapsone belongs to Anti Bacterial.

證據等級: Low

為什麼會發生

Cobicistat inhibits CYP3A4, which contributes to dapsone metabolism.

處置方式

Monitor blood counts and methemoglobin symptoms, especially in G6PD-deficient patients. Reduce the dapsone dose if toxicity appears.

可向藥師詢問的問題

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ 會員專屬

解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可解鎖 Cobicistat 與 Dapsone 的完整臨床處置建議、補充說明、證據詳情及整張處方的交互作用檢查工具。

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
建立免費帳號 登入

在網頁版免費試用 Pro+ 7 天，無需信用卡。

常見問題

Can I take Cobicistat with Dapsone?

MediHelp rates the interaction as moderate. Cobicistat and Dapsone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat is a strong CYP3A4 inhibitor and may increase dapsone exposure. Higher dapsone levels could raise the risk of dose-related hemolysis and methemoglobinemia.

How serious is the interaction between Cobicistat and Dapsone?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and methemoglobin symptoms, especially in G6PD-deficient patients. Reduce the dapsone dose if toxicity appears.

What other medicines interact with Dapsone?

MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.

在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查

在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。

下載於App Store 立即下載Google Play

依 A–Z 瀏覽 · 藥物交互作用

取得 App 登入