藥物交互作用
Cocaine + Duloxetine
嚴重程度: 嚴重
Cocaine and Duloxetine: major interaction.
最後更新
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摘要
Cocaine blocks reuptake of serotonin, norepinephrine and dopamine, so systemic cocaine use with duloxetine may increase serotonin toxicity and cardiovascular stimulation. Topical medical cocaine has little systemic absorption, so the risk is mostly with illicit or high-dose use.
用白話說明這項交互作用的意義
Cocaine and Duloxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cocaine belongs to Central Nervous System; Duloxetine belongs to Central Nervous System.
為什麼會發生
Additive monoamine reuptake inhibition causing serotonergic and sympathomimetic effects.
處置方式
Counsel patients to avoid cocaine use and monitor for serotonin syndrome, hypertension and tachycardia if exposure occurs. For topical use, limit dose to the minimum needed.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Duloxetine 的其他交互作用
Cocaine 的其他交互作用
常見問題
Can I take Cocaine with Duloxetine?
MediHelp rates the interaction as major. Cocaine and Duloxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cocaine blocks reuptake of serotonin, norepinephrine and dopamine, so systemic cocaine use with duloxetine may increase serotonin toxicity and cardiovascular stimulation. Topical medical cocaine has little systemic absorption, so the risk is mostly with illicit or high-dose use.
How serious is the interaction between Cocaine and Duloxetine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid cocaine use and monitor for serotonin syndrome, hypertension and tachycardia if exposure occurs. For topical use, limit dose to the minimum needed.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
