藥物交互作用
Colchicine + Danicopan
嚴重程度: 中度
Colchicine and Danicopan: moderate interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Danicopan inhibits P-glycoprotein and can raise concentrations of P-gp substrates such as colchicine. Because colchicine has a narrow therapeutic index, increased exposure may cause toxicity.
用白話說明這項交互作用的意義
Colchicine and Danicopan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colchicine belongs to Genitourinary; Danicopan belongs to Miscellaneous.
為什麼會發生
P-glycoprotein inhibition by danicopan reduces colchicine efflux.
處置方式
Consider reducing the colchicine dose and monitor for gastrointestinal, neuromuscular and hematologic toxicity, particularly in renal impairment.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Colchicine 的其他交互作用
Danicopan 的其他交互作用
常見問題
Can I take Colchicine with Danicopan?
MediHelp rates the interaction as moderate. Colchicine and Danicopan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-glycoprotein and can raise concentrations of P-gp substrates such as colchicine. Because colchicine has a narrow therapeutic index, increased exposure may cause toxicity.
How serious is the interaction between Colchicine and Danicopan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the colchicine dose and monitor for gastrointestinal, neuromuscular and hematologic toxicity, particularly in renal impairment.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
