藥物交互作用
Crizotinib + Nirogacestat
嚴重程度: 嚴重
Crizotinib and Nirogacestat: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Nirogacestat is a CYP3A4 substrate, so crizotinib can increase its exposure. This may increase diarrhea, hepatotoxicity and other dose-related effects.
用白話說明這項交互作用的意義
Crizotinib and Nirogacestat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Crizotinib belongs to Oncology; Nirogacestat belongs to Oncology.
為什麼會發生
Crizotinib inhibits CYP3A4 metabolism of nirogacestat.
處置方式
Avoid the combination if possible. If necessary, monitor liver tests and gastrointestinal toxicity and consider a nirogacestat dose reduction.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Crizotinib 的其他交互作用
Nirogacestat 的其他交互作用
常見問題
Can I take Crizotinib with Nirogacestat?
MediHelp rates the interaction as major. Crizotinib and Nirogacestat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nirogacestat is a CYP3A4 substrate, so crizotinib can increase its exposure. This may increase diarrhea, hepatotoxicity and other dose-related effects.
How serious is the interaction between Crizotinib and Nirogacestat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If necessary, monitor liver tests and gastrointestinal toxicity and consider a nirogacestat dose reduction.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
