藥物交互作用

Crizotinib + Pimozide

嚴重程度: 禁忌併用

Crizotinib and Pimozide: contraindicated interaction.

最後更新 12 十月 2026

僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。

本頁的臨床內容僅提供英文版。

摘要

Pimozide prolongs the QTc interval and is a CYP3A4 substrate, and crizotinib lengthens the QTc interval, causes bradycardia and inhibits CYP3A4. Together they raise the risk of torsades de pointes and sudden cardiac death.

用白話說明這項交互作用的意義

Crizotinib and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Crizotinib belongs to Oncology; Pimozide belongs to Central Nervous System.

證據等級: Moderate

為什麼會發生

Additive QTc prolongation; CYP3A4 inhibition by crizotinib raises pimozide exposure

處置方式

Do not co-administer; choose an alternative that does not prolong the QT interval.

可向藥師詢問的問題

Is there an alternative to one of these two medicines for me?
If both are essential, who is monitoring me and how often?
Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Pro+ 會員專屬

解鎖完整頁面

建立帳號並開始 Pro+ 試用，即可解鎖 Crizotinib 與 Pimozide 的完整臨床處置建議、補充說明、證據詳情及整張處方的交互作用檢查工具。

Full clinical management advice
Additional notes
Evidence detail
Interaction checker for a whole prescription

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常見問題

Can I take Crizotinib with Pimozide?

MediHelp rates the interaction as contraindicated. Crizotinib and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Pimozide prolongs the QTc interval and is a CYP3A4 substrate, and crizotinib lengthens the QTc interval, causes bradycardia and inhibits CYP3A4. Together they raise the risk of torsades de pointes and sudden cardiac death.

How serious is the interaction between Crizotinib and Pimozide?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; choose an alternative that does not prolong the QT interval.

What other medicines interact with Pimozide?

MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.

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摘要