藥物交互作用
Cyclosporin + Lornoxicam
嚴重程度: 嚴重
Cyclosporin and Lornoxicam: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Lornoxicam combined with cyclosporine increases the risk of nephrotoxicity, hypertension and fluid retention. Reduced renal blood flow from both agents is additive.
用白話說明這項交互作用的意義
Cyclosporin and Lornoxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Lornoxicam belongs to Musculoskeletal.
為什麼會發生
NSAID inhibition of vasodilatory renal prostaglandins adds to cyclosporine-induced renal vasoconstriction.
處置方式
Avoid the combination where possible and use an alternative analgesic such as paracetamol. If it is used, monitor serum creatinine, potassium and blood pressure closely.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Cyclosporin 的其他交互作用
Lornoxicam 的其他交互作用
常見問題
Can I take Cyclosporin with Lornoxicam?
MediHelp rates the interaction as major. Cyclosporin and Lornoxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lornoxicam combined with cyclosporine increases the risk of nephrotoxicity, hypertension and fluid retention. Reduced renal blood flow from both agents is additive.
How serious is the interaction between Cyclosporin and Lornoxicam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use an alternative analgesic such as paracetamol. If it is used, monitor serum creatinine, potassium and blood pressure closely.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
