藥物交互作用
Amlodipine-olmesartan-hydrochlorothiazide + Lornoxicam
嚴重程度: 嚴重
Amlodipine-olmesartan-hydrochlorothiazide and Lornoxicam: major interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
NSAIDs such as lornoxicam can blunt the antihypertensive effect of olmesartan and hydrochlorothiazide, and the combination of an NSAID, an angiotensin receptor blocker and a diuretic raises the risk of acute kidney injury, especially in older or volume-depleted patients. Potassium retention may also occur.
用白話說明這項交互作用的意義
Amlodipine-olmesartan-hydrochlorothiazide and Lornoxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Lornoxicam belongs to Musculoskeletal.
為什麼會發生
NSAID inhibition of renal prostaglandin synthesis causes sodium and water retention and reduces glomerular perfusion when angiotensin II blockade and diuresis are also present.
處置方式
Avoid regular NSAID use where possible and use the lowest dose for the shortest time if needed. Maintain hydration and monitor blood pressure, serum creatinine and potassium.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Amlodipine-olmesartan-hydrochlorothiazide 的其他交互作用
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide 禁忌併用
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide 禁忌併用
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan 禁忌併用
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide 嚴重
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide 嚴重
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide 嚴重
Lornoxicam 的其他交互作用
常見問題
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Lornoxicam?
MediHelp rates the interaction as major. Amlodipine-olmesartan-hydrochlorothiazide and Lornoxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs such as lornoxicam can blunt the antihypertensive effect of olmesartan and hydrochlorothiazide, and the combination of an NSAID, an angiotensin receptor blocker and a diuretic raises the risk of acute kidney injury, especially in older or volume-depleted patients. Potassium retention may also occur.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Lornoxicam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use where possible and use the lowest dose for the shortest time if needed. Maintain hydration and monitor blood pressure, serum creatinine and potassium.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
