藥物交互作用
Amlodipine-hydrochlorothiazide-valsartan + Lornoxicam
嚴重程度: 嚴重
Amlodipine-hydrochlorothiazide-valsartan and Lornoxicam: major interaction.
最後更新
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本頁的臨床內容僅提供英文版。
摘要
Lornoxicam may reduce the antihypertensive effect of valsartan and hydrochlorothiazide and increases the risk of acute kidney injury and hyperkalemia with an ARB plus diuretic, particularly in elderly or dehydrated patients.
用白話說明這項交互作用的意義
Amlodipine-hydrochlorothiazide-valsartan and Lornoxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Lornoxicam belongs to Musculoskeletal.
為什麼會發生
NSAID inhibition of renal prostaglandins causes sodium retention and reduced renal perfusion that is dependent on angiotensin blockade.
處置方式
Avoid regular use where possible, otherwise use the lowest dose for the shortest time with hydration. Monitor blood pressure, creatinine, and potassium.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Amlodipine-hydrochlorothiazide-valsartan 的其他交互作用
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan 禁忌併用
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide 禁忌併用
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan 禁忌併用
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan 嚴重
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan 嚴重
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan 嚴重
Lornoxicam 的其他交互作用
常見問題
Can I take Amlodipine-hydrochlorothiazide-valsartan with Lornoxicam?
MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Lornoxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lornoxicam may reduce the antihypertensive effect of valsartan and hydrochlorothiazide and increases the risk of acute kidney injury and hyperkalemia with an ARB plus diuretic, particularly in elderly or dehydrated patients.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Lornoxicam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular use where possible, otherwise use the lowest dose for the shortest time with hydration. Monitor blood pressure, creatinine, and potassium.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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