藥物交互作用
Celecoxib + Lornoxicam
嚴重程度: 嚴重
Celecoxib and Lornoxicam: major interaction.
最後更新
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摘要
Combining two NSAIDs adds no proven benefit and increases the risk of gastrointestinal bleeding, renal injury and cardiovascular events. Lornoxicam is a nonselective NSAID with significant GI toxicity.
用白話說明這項交互作用的意義
Celecoxib and Lornoxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Celecoxib belongs to Musculoskeletal; Lornoxicam belongs to Musculoskeletal.
為什麼會發生
Additive inhibition of cyclooxygenase, with duplicated effects on gastric mucosa, platelets and renal prostaglandins.
處置方式
Avoid concurrent use of two NSAIDs and use a single agent at the lowest effective dose. If a switch is made, stop one agent before starting the other.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Celecoxib 的其他交互作用
Lornoxicam 的其他交互作用
常見問題
Can I take Celecoxib with Lornoxicam?
MediHelp rates the interaction as major. Celecoxib and Lornoxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two NSAIDs adds no proven benefit and increases the risk of gastrointestinal bleeding, renal injury and cardiovascular events. Lornoxicam is a nonselective NSAID with significant GI toxicity.
How serious is the interaction between Celecoxib and Lornoxicam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two NSAIDs and use a single agent at the lowest effective dose. If a switch is made, stop one agent before starting the other.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
