藥物交互作用
Dabigatran etexilate + Danicopan
嚴重程度: 中度
Dabigatran etexilate and Danicopan: moderate interaction.
最後更新
僅供醫療專業人員參考。本頁為簡要摘要，並非醫療建議，亦不能取代官方仿單或臨床判斷。開立處方或調劑前請務必核實。
本頁的臨床內容僅提供英文版。
摘要
Danicopan increases exposure to P-gp substrates, and dabigatran levels may rise, increasing bleeding risk.
用白話說明這項交互作用的意義
Dabigatran etexilate and Danicopan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabigatran etexilate belongs to Cardiovascular; Danicopan belongs to Miscellaneous.
為什麼會發生
Inhibition of intestinal P-glycoprotein efflux of dabigatran etexilate.
處置方式
Monitor for bleeding and consider dabigatran dose reduction, particularly with renal impairment. Separating doses may reduce the intestinal effect.
可向藥師詢問的問題
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Dabigatran etexilate 的其他交互作用
Danicopan 的其他交互作用
常見問題
Can I take Dabigatran etexilate with Danicopan?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Danicopan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan increases exposure to P-gp substrates, and dabigatran levels may rise, increasing bleeding risk.
How serious is the interaction between Dabigatran etexilate and Danicopan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and consider dabigatran dose reduction, particularly with renal impairment. Separating doses may reduce the intestinal effect.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
