藥物交互作用
Deferasirox + Metformin-repaglinide
嚴重程度: 嚴重
Deferasirox and Metformin-repaglinide: major interaction.
最後更新
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摘要
Deferasirox inhibits CYP2C8 and can substantially raise repaglinide exposure, which increases the risk of hypoglycemia. Repaglinide is a sensitive CYP2C8 substrate, and the combination has been studied pharmacokinetically.
用白話說明這項交互作用的意義
Deferasirox and Metformin-repaglinide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferasirox belongs to Miscellaneous; Metformin-repaglinide belongs to Endocrine.
為什麼會發生
Inhibition of CYP2C8 (and to a lesser extent CYP3A4) metabolism of repaglinide.
處置方式
Avoid the combination if possible; otherwise reduce the repaglinide dose and monitor blood glucose closely.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Metformin-repaglinide 的其他交互作用
Deferasirox 的其他交互作用
常見問題
Can I take Deferasirox with Metformin-repaglinide?
MediHelp rates the interaction as major. Deferasirox and Metformin-repaglinide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Deferasirox inhibits CYP2C8 and can substantially raise repaglinide exposure, which increases the risk of hypoglycemia. Repaglinide is a sensitive CYP2C8 substrate, and the combination has been studied pharmacokinetically.
How serious is the interaction between Deferasirox and Metformin-repaglinide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise reduce the repaglinide dose and monitor blood glucose closely.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
