藥物交互作用
Clopidogrel + Metformin-repaglinide
嚴重程度: 嚴重
Clopidogrel and Metformin-repaglinide: major interaction.
最後更新
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摘要
Clopidogrel's acyl glucuronide metabolite inhibits CYP2C8 and increases repaglinide exposure substantially, raising the risk of hypoglycemia.
用白話說明這項交互作用的意義
Clopidogrel and Metformin-repaglinide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clopidogrel belongs to Cardiovascular; Metformin-repaglinide belongs to Endocrine.
為什麼會發生
Inhibition of CYP2C8-mediated repaglinide metabolism by clopidogrel's glucuronide metabolite.
處置方式
Avoid the combination if possible; if needed, begin repaglinide at 0.5 mg per meal and do not exceed 4 mg daily. Monitor blood glucose closely.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Metformin-repaglinide 的其他交互作用
Clopidogrel 的其他交互作用
常見問題
Can I take Clopidogrel with Metformin-repaglinide?
MediHelp rates the interaction as major. Clopidogrel and Metformin-repaglinide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clopidogrel's acyl glucuronide metabolite inhibits CYP2C8 and increases repaglinide exposure substantially, raising the risk of hypoglycemia.
How serious is the interaction between Clopidogrel and Metformin-repaglinide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if needed, begin repaglinide at 0.5 mg per meal and do not exceed 4 mg daily. Monitor blood glucose closely.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
