藥物交互作用
Apalutamide + Metformin-repaglinide
嚴重程度: 嚴重
Apalutamide and Metformin-repaglinide: major interaction.
最後更新
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摘要
Apalutamide is a strong CYP3A4 and CYP2C8 inducer and can substantially reduce repaglinide exposure. This may cause loss of glycemic control.
用白話說明這項交互作用的意義
Apalutamide and Metformin-repaglinide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Metformin-repaglinide belongs to Endocrine.
為什麼會發生
Induction of CYP3A4 and CYP2C8 metabolism of repaglinide by apalutamide.
處置方式
Monitor blood glucose closely and titrate repaglinide upward if needed, or switch to an alternative antidiabetic agent. Reassess dosing after apalutamide is stopped.
可向藥師詢問的問題
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Metformin-repaglinide 的其他交互作用
Apalutamide 的其他交互作用
常見問題
Can I take Apalutamide with Metformin-repaglinide?
MediHelp rates the interaction as major. Apalutamide and Metformin-repaglinide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide is a strong CYP3A4 and CYP2C8 inducer and can substantially reduce repaglinide exposure. This may cause loss of glycemic control.
How serious is the interaction between Apalutamide and Metformin-repaglinide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and titrate repaglinide upward if needed, or switch to an alternative antidiabetic agent. Reassess dosing after apalutamide is stopped.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Metformin-repaglinide page.
在 MediHelp App 中取得完整藥品專論、劑量資訊與交互作用檢查
在 MediHelp App 中開啟完整參考資料、檢查多種藥物間的交互作用，並使用劑量工具。
